In this new study published by Brain Communications, volunteers with self-reported fatigue after a mild COVID infection carried out a battery of behavioural and neurophysiological tests assessing the central, peripheral and autonomic nervous systems. In comparison with age- and sex-matched volunteers without fatigue, the results show underactivity in specific cortical circuits, dysregulation of autonomic function and myopathic change in skeletal muscle.
Furthermore, cluster analysis revealed no subgroupings, suggesting post-COVID fatigue is a single entity with individual variation, rather than a small number of distinct syndromes.
Neural dysregulation in post-COVID fatigue | Brain Communications | Oxford Academic (oup.com)
