Effectiveness of mindfulness-based online therapy or internet-delivered cognitive behavioral therapy compared with treatment as usual among patients with persistent somatic symptoms: Protocol for a randomized controlled trial

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“Effectiveness of mindfulness-based online therapy or internet-delivered cognitive behavioral therapy compared with treatment as usual among patients with persistent somatic symptoms: Protocol for a randomized controlled trial”

Don’t miss our latest study protocol by Vangelova-Korpinen et al.  which has been published recently in the PLOS One Journal.

This study protocol investigates the effect of the following two online interventions:

  • a mindfulness-based amygdala and insula retraining (AIR) program and
  • ACT-based internet therapy (HUS iCBTpss)

The aim of this study is to explore the effect of the AIR program and the HUS iCBTpss on the patients’ self-assessment of functional ability and quality of life as compared to treatment as usual (TAU).

This study performed a randomized controlled trial with 360 patients. Consenting patients has been randomized to three study arms: online AIR program, HUS iCBTpss (both interventions as add-ons to TAU); and TAU. Functional ability and quality of life surveys were collected from participants at baseline and at 3, 6, and 12 months after entering the study.

For further details, read the full article here: Long COVID publications.

Vangelova-Korpinen, V., Liira, H., Kurki, S. N., Sainio, M., Malmivaara, A., Kanerva, M., Stenberg, J. H., Varonen, M., Venäläinen, M., Vuorela, P., & Arokoski, J. (2025). Effectiveness of mindfulness-based online therapy or internet-delivered cognitive behavioral therapy compared with treatment as usual among patients with persistent somatic symptoms: Protocol for a randomized controlled trial. PloS one20(2), e0316169. https://doi.org/10.1371/journal.pone.0316169