Very interesting position paper led by Dr. Amy Proal reviewing studies that have identified SARS-CoV-2 RNA/protein or immune responses indicative of a SARS-CoV-2 reservoir in post-acute sequelae of COVID-19 (PASC) samples.
“SARS-CoV-2 reservoir may drive inflammatory, coagulation, microbiome, neuroimmune and other abnormalities in PASC. Future research should focus on determining if SARS-CoV-2 persistence varies by cell type or body site, by viral variant, and should further delineate mechanisms by which SARS-CoV-2 evades immune detection or elimination to persist in human tissue.”
This review article has been published by Nature Immunology.
SARS-CoV-2 reservoir in post-acute sequelae of COVID-19 (PASC) | Nature Immunology
