Humoral immunity to an endemic coronavirus is associated with postacute sequelae of COVID-19 in individuals with rheumatic diseases

Why do some people infected with COVID-19 develop postacute sequelae of COVID-19 (PASC) while others do not?

This is the question that Herman et al. try to answer with this recently published study. The article shows that the presence of functional antibodies specific to OC43 (endemic human coronavirus) was enriched in PASC, suggesting immunological imprinting specific to OC43 may be a driver of PASC, particularly in individuals with prior rheumatic disease. 

Humoral immunity to an endemic coronavirus is associated with postacute sequelae of COVID-19 in individuals with rheumatic diseases | Science Translational Medicine