Don’t miss the remarkable letter, which recently has been published in the Nature Immunology Journal by Liew et. al.
About 1 in 10 people infected with the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) experience prolonged symptoms known as long COVID. However, the different types of the disease and their underlying mechanisms are not fully understood yet.
The researchers profiled 368 plasma proteins in 657 individuals who had been hospitalised for at least 3 months. Among them, 426 had ongoing long COVID symptoms while 233 had fully recovered.
„Our study aimed to understand inflammatory processes that underlie long COVID and was not designed for biomarker discovery. Our findings suggest that specific inflammatory pathways related to tissue damage are implicated in subtypes of long COVID, which might be targeted in future therapeutic trials.“ (Liew et al., 2024)
Liew, F., Efstathiou, C., Fontanella, S. et al. Large-scale phenotyping of patients with long COVID post-hospitalization reveals mechanistic subtypes of disease. Nat Immunol 25, 607–621 (2024). https://doi.org/10.1038/s41590-024-01778-0
