In this study published by the Infection journal, during the first pandemic phase, more than 175 COVID-19 patients from a prospective cohort were stratified by initial disease severity and underwent clinical, psychosocial, and immune phenotyping around 10 weeks after first COVID-19 symptoms. The authors of this article assessed COVID-19-associated fatigue dynamics, relating them to clinical and immune phenotypes.
“The independent correlation between fatigue severity and blood T cell phenotypes indicates a possible role of CD4+ T cells in the pathogenesis of post-COVID-19 fatigue, which might serve as a blood biomarker.”
